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Narrow your search by typing as much as the drug/product name as possible to limit your search results.
Clinical Pharmacology offers the ability to create an IV Compatibility report for multiple medications given via different methods utilizing the data from the Trissel’s™ 2 Clinical Pharmaceutics Database and Trissel’s™ Tables of Physical Compatibility. Results are presented in an easy to read table that allows users to quickly assess compatibility and provides additional information with a single click.
Click here for an example of an IV Compatibility Report.
From the Clinical Pharmacology home page, click the Reports menu and select IV Compatibility Report.
From the text box enter a drug/product name. As you type the letters into the search text box, Clinical Pharmacology presents drug/product names. Either click one of the suggested drug/product names or click the Add button when your result displays in the text box.
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Narrow your search by typing as much as the drug/product name as possible to limit your search results. |
The drug adds to the right under Report Criteria. The drug/product displays a red 'X' to its left.
If you decide you want to remove a drug name on the right, click the red 'X" in front of the name of the drug you want to remove.
Add additional drugs to your report criteria by repeating Step 2.
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If you need to remove a drug product from the Report Criteria, click the red 'X' to the left of the drug product. |
Click the 
(Run
Report) button.
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IV Compatibility report results are separated by administration method: Admixture, Y-site, and syringe. Only if there are reportable results for a particular administration method will a table appear. If there are no compatibility study results for syringe administration for the drugs included in the IV Compatibility report, the syringe result table will not appear. |
When viewing the report tables, the compatibility information will be identified in one of the following four ways:
Click here for (Compatible) sample details.
If the study indicates one or more of the following outcomes, the results will be designated as compatible:
No change in visible or electronically-determined particulates, haziness or turbidity, frank precipitation, color, or evolution of gas.
All drug components in the test samples are found to be chemically stable, (<10% loss of intact drug), for at least 24 hours under the conditions being tested.
All drug components in test samples are found to be chemically stable, (<10% loss of intact drug), for the entire study period under the conditions being tested, even if the study period was <24 hours.
NOTE: Some admixtures that lose >10% of the intact drug in 24 hours or are tested for less than 24 hours may be used for lesser time periods.
Click here for (Incompatible) sample details.
If the study indicates one or more of the following outcomes, the results will be designated as incompatible:
A change in visible or electronically-determined (even if not visible) particulates, haziness or turbidity, frank precipitation, color, or gas evolution occurs.
One or more of the drug components in the test samples exhibits a loss of intact drug >10% within 24 hours under the conditions being tested.
Click here for (Results uncertain, variable or dependent on conditions) sample details.
If the study results do not fit conventional compatible or incompatible guidelines, the results are designated as "Results uncertain, variable or dependent on conditions." Judgment will need to be applied when evaluating these results. Examples of such results include:
A transient precipitation formed upon mixing but then disappeared. The precipitate may or may not appear again later.
Among repeat test samples, microparticulate formation was electronically determined to have formed in some samples but not others.
The test drug in a solution was stable in one container type but not another, or with some drug delivery devices but not others.
Compatibility of a drug or drugs is dependent upon the individual manufacturer(s) formulation of the products and/or the use of specific product formulations.
Any other research result that does not fit the conventional guidelines of compatibility or incompatibility.
If the IV Compatibility results indicate that no data is available, then there is no data available within the Trissel’s™ 2 Clinical Parmaceutics Database and/or Trissel’s™ Tables of Physical Compatibility regarding the compatibility of the drugs and/or solutions.
Within the tables, you are able to click on 
, 
, or 
to display the compatibility study details.
If there is more than 1 study available, you will see "1 of X" and an arrow to page through the multiple study results. Click here for an illustrated example of this.
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The compatibility report will be grouped by routes; (i.e. Admixture, Syringe, and YSite). |
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Interpreting Variable Study Results When IV Compatibility results that yield a single study or several studies with consistent results, interpretation of the results is straight forward. However, when results are uncertain, variable or dependent upon administration conditions, interpretation becomes much more difficult. Most variability in study results relates to differences in critical study factors, which may include:
If studies of the same drug and/or solution combinations have differing results, look for and identify factors, such as concentration dependency or solution dependency (among others), that may have caused the difference. In addition, the Notations section may direct your attention to the existence of varying results that are included in the data along with possible sources for that variability when they can be ascertained. |
To print the report, click the 
(printer)
icon in the upper right. A popup window opens with the report. Again,
click the printer icon in the upper right and follow your normal printing
procedures.
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Once you have run a report you can redisplay the last search for each of the reports one at-a-time from your current open session of Clinical Pharmacology. For example, the recent reports keep track of the last report run for each of the individual reports – so the last drug interaction report, the last IV compatibility report, and so on. Recent Reports is a link located at the top of the Clinical Pharmacology header. |
The IV Compatibility Pro add-on module offers more extensive compatibility study information from the Trissel’s™ 2 Clinical Pharmaceutics Database. With this module, the following will be available with the IV Compatibility information:
Detailed information regarding the IV Compatibility study performed including the drug concentrations studied and study parameters such as the analytical method, duration, storage conditions, and the container used, as well as the reference citation.
Chemical stability information provided (where available).
As is illustrated below, this module includes additional links as part of the compatibility details popup window; (i.e. Chemical Stability, Method, Storage Conditions, Container, and Duration). As each link is clicked, the text at the bottom of this window will change accordingly, providing you with greater information and detail about the compatibility study that was performed.
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